THE RELEASE OF NEUROHYPOPHYSIAL HORMONE BY SOUND

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Abstract
SUMMARY: Thunderclaps, recorded and replayed, and a sound frequency of 150 cyc./sec. at 98–100 decibels increased the urinary excretion of Na+ and K+ of normal but not of neurohypophysectomized rats; 150 cyc./sec. also increased urine flow. The urinary changes induced by a sound frequency of 150 cyc./sec. closely resembled those caused by the s.c. injection of 4 m-u. oxytocin. Adrenaline hydrochloride, 0·5–10 μg./100 g. body weight, given s.c., caused antidiuresis, and reduced urinary Na+ and K+; 40 μg. adrenaline increased urine flow, and Na+ and K+ excretion. The Na:K ratio in the urine rose as the dose of adrenaline was increased. The effect of 5 μg. adrenaline/100 g. given s.c. to rats with denervated kidneys was much the same as that of 40 μg./100 g. in unoperated rats. Five μg. adrenaline, given subcutaneously, completely antagonized the urinary changes induced by 4 m-u. oxytocin in normal, and adrenalectomized rats, and in animals with denervated kidneys or treated with propylthiouracil. However, the oxytocin-induced kaliuresis in neurohypophysectomized rats was not antagonized. Vasopressin, 0·2–3·0 m-u. s.c., caused antidiuresis without changes in urinary Na+ and K+ excretion; 6·0 m-u. delayed water excretion markedly and increased urinary Na+ and K+ output. The urinary changes induced by replayed thunder were attributable to the release of oxytocin together with a lesser amount of vasopressin. By contrast a sound frequency of 150 cyc./sec. probably released oxytocin alone.

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