Über die Pasteursche Reaktion im Warmblütermuskelbrei

Publisher Website
Google Scholar
Abstract
If the cells of warm-blooded animals, especially muscle cells, are placed in an anaerobic atmosphere, a pronounced catabolism of glycogen to lactic acid takes place. If O2 is admitted to the system, cell respiration begins, the formation of lactic acid actually ceases, and the carbohydrate is decomposed by oxidation. This phenomenon is known as the "Pasteur reaction." Injury to the cells during hashing or an excess of glycogen in the tissues may interfere with the reaction so that some lactic acid is formed in the presence of O2. Injury to the cells results in a disturbance of the H transport in. that part of the oxidative system which lies between the substrate and the succinic acid-fumaric acid system. Tissues should be minced fine with scissors rather than ground in a meat grinder. In glycogen rich muscle it is believed that the rate of formation of triose phosphates is greater than their dehydrogenation by O2 so that lactic acid is formed. It seems that the oxalacetic acid-malic acid system participates directly in the Pasteur reaction, while the succinate-fumarate system accepts the H of the substrate from the malic acid. The abnormal formation of lactic acid in the presence of O2 can be inhibited by the addition of a CH4-dicarboxylic acid to the muscle hash.

This publication has 3 references indexed in Scilit: