EXPERIMENTAL STUDIES ON SARCOIDOSIS

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Abstract
SARCOIDOSIS is a disease for which various etiologic and immunologic concepts have been advanced. Many have thought the condition to be of tuberculous origin. However, there were certain difficulties in the acceptance of the view of a tuberculous causation. The chief of these were that the tubercle bacillus could but rarely be cultured from patients with the disease and that the majority of persons with sarcoidosis manifested markedly reduced reactivity toward tuberculin. J. Jadassohn, in an endeavor to reconcile these findings with a tuberculous origin, hypothesized that persons with sarcoidosis actually had a special form of immunity toward the tubercle bacillus. He theorized that persons with this form of immunity disposed of the tubercle bacillus or its products so rapidly that the organism was rarely found or that the tuberculin did not have an adequate opportunity to produce its usual type of reaction. This theory has recently

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