Antigen processing mutant T2 cells present viral antigen restricted through H‐2K
- 1 August 1993
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 23 (8) , 1802-1808
- https://doi.org/10.1002/eji.1830230811
Abstract
Cytotoxic T lymphocytes (CTL) recognize foreign antigens as short peptides presented by class I molecules of the major histocompatibility complex (MHC). T2 cells are profoundly defective in the presentation of endogenously synthesized antigens to CTL due to a deletion of MHC class II-encoded genes for transporters associated with antigen presentation (TAP1/TAP2). Surprisingly, we here demonstrate that T2 cells, after infection with Sendai virus, are readily killed by H-2Kb restricted CD8+ T cells. In contrast to classical class I-mediated antigen presentation, the presentation of Sendai virus antigen inT2Kb cells is brefeldin A (BFA) insensitive. The present findings may suggest the presence of an alternative pathway for MHC class I-mediated antigen presentation in T2 cells.Keywords
This publication has 42 references indexed in Scilit:
- In vivo priming of cytotoxic T lymphocyte responses in relation to in vitro up‐regulation of major histocompatibility complex class I molecules by short synthetic peptidesEuropean Journal of Immunology, 1992
- HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptidesNature, 1992
- A new presentation pathway?Nature, 1992
- Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporterNature, 1991
- Transport Protein Genes in the Murine MHC: Possible Implications for Antigen ProcessingScience, 1990
- A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathwayNature, 1990
- Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transportersNature, 1990
- MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transportersNature, 1990
- Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.The Journal of Experimental Medicine, 1985
- Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigensHuman Immunology, 1984