The Leakage Characteristics of Liposome-Encapsulated Adriamycin-Dextran Conjugates

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Abstract
The leakage characteristics of liposome- encapsulated adriamycin-dextran conjugates was investigated. The results of in vitro studies indicate that the leakage of adriamycin-dextran TI0 conjugate and adriamycin from liposomes was a diffusion process. The results of in vivo studies show that the half-life of plasma clearance of adriamycin-dextran conjugates was greatly enhanced. The larger molecular size of the encapsulated drugs caused a slower half-life of clearance. This probably resulted from a slower rate of diffusion.