Does “Self-taming” with Succinylcholine Prevent Postoperative Myalgia?

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Abstract
Muscle fasciculations associated with succinylcholine [in humans] can be decreased or eliminated by administering a small dose (10 mg) of succinylcholine before giving the full paralyzing dose. Does this self-taming technique prevent post-succinylcholine muscle pains? Pretreatment with a small amount of nondepolarizing muscle relaxant prior to giving succinylcholine is an effective means of preventing muscle fasciculations. This technique may not provide for optimal intubation conditions since there is an antagonistic interaction between the nondepolarizing agent and succinylcholine. Although the incidence and degree of fasciculations from succinylcholine can be decreased by pretreatment with a 10 mg dose of the drug, this self-taming technique offers no advantage in decreasing the occurrence or severity of postoperative myalgia.

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