What’s new in β-lactamases?
- 1 February 2001
- journal article
- Published by Springer Nature in Current Infectious Disease Reports
- Vol. 3 (1) , 13-19
- https://doi.org/10.1007/s11908-001-0054-z
Abstract
Beta-lactamases continue to be the leading cause of resistance to beta-lactam antibiotics, among gram-negative bacteria. In recent years, both the incidence and the prevalence of extended-spectrum beta-lactamases, inhibitor-resistant beta-lactamases, AmpC-type enzymes, and both metallo- carbapenemases and nonmetallo-carbapenemases have increased. These beta-lactamases provide resistance to oximino-cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, cephamycins, and carbapenems, respectively. Strains expressing these beta-lactamases will generate a host of therapeutic challenges as we begin the 21st century.Keywords
This publication has 63 references indexed in Scilit:
- β-Lactamases in Shigella flexneri Isolates from Hong Kong and Shanghai and a Novel OXA-1-Like β-Lactamase, OXA-30Antimicrobial Agents and Chemotherapy, 2000
- Outbreak ofKlebsiella pneumoniaeproducing transferable AmpC-type β-lactamase (ACC-1) originating fromHafnia alveiFEMS Microbiology Letters, 2000
- Ceftriaxone-Resistant Salmonella Infection Acquired by a Child from CattleNew England Journal of Medicine, 2000
- Control of a Prolonged Outbreak of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in a University HospitalClinical Infectious Diseases, 1999
- Mutations in theampCpromoter ofEscherichia coliisolates resistant to oxyiminocephalosporins without extended spectrum β-lactamase productionFEMS Microbiology Letters, 1999
- Two novel plasmid-mediated cefotaxime-hydrolyzing β-lactamases (CTX-M-5 and CTX-M-6) fromSalmonella typhimuriumFEMS Microbiology Letters, 1998
- Novel metallo β-lactamase mediated by aShigella flexneriplasmidFEMS Microbiology Letters, 1998
- Tazobactam is a potent inactivator of selected inhibitor-resistant class A β-lactamasesFEMS Microbiology Letters, 1997
- A new plasmidic cefotaximase from patients infected withSalmonella typhimuriumInfection, 1992
- OHIO-1 β-lactamase resistant to mechanism-based inactivatorsFEMS Microbiology Letters, 1992