CALCIUM AND PHOSPHORUS METABOLISM IN DISEASES OF THE THYROPARATHYROID APPARATUS. II. CALCIUM AND PHOSPHORUS BALANCE (A) FOLLOWING THERAPEUTIC RADIATION OF THE HYPERPLASTIC THYROID GLAND, AND (B) IN HYPERTHYROIDIC PATIENTS TREATED WITH IODINE

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Abstract
The Ca and P balance of a series of 27 hyperthyroidic patients was compared with the degree of hyperthyroidism as measured by the level of the basal metabolic rate (B.M.R.). Untreated patients were in general in negative Ca and P balance, but the degree of loss was not directly related to the level of the B.M.R. Patients treated with I were generally in negative Ca and P balance, but again the extent of the Ca and P loss was not proportional to the level of the B.M.R. 2 mos. or more after therapeutic irradiation of the thyroid region the Ca and P balance tended to become positive, though the B.M.R. was still raised. Statistical analysis of the results showed that there was no relationship whatsoever between the state of the Ca and P balance and the degree of hyperthyroidism as measured by the B.M.R. The authors concluded that an associated hyperactivity of the parathyroid glands was the most probable cause of the Ca and P loss, and that these glands were more radio-sensitive than the hyperplastic thyroid gland.

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