Serotypes of Chlamydia trachomatis and Risk for Development of Cervical Squamous Cell Carcinoma
Top Cited Papers
Open Access
- 3 January 2001
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 285 (1) , 47-51
- https://doi.org/10.1001/jama.285.1.47
Abstract
Human papillomavirus (HPV) infection is the leading cause of cervical neoplasia.1-3 Additional risk factors include other sexually transmitted infections (STIs) and smoking. The evidence linking oncogenic HPV types and cervical carcinoma is very strong and consistent. Human papillomavirus DNA–based cohort studies4,5 have confirmed the seroepidemiologic findings6,7 that past HPV infection predisposes women to developing cervical carcinoma. Longitudinal seroepidemiologic studies have also provided evidence that Chlamydia trachomatis infection is an independent risk factor for the development of invasive cervical squamous cell carcinoma (SCC).6-8 Cervical chlamydial infection can persist for long periods of time.9 Similarly, elevated antichlamydial antibody titers persist for several years.10 Microimmunofluorescence (MIF) testing is still the gold standard for chlamydia serology, and researchers also can use MIF for serotyping.11,12 We found a link between the presence of serum antibodies to C trachomatis and the subsequent development of cervical SCC.8 This study was conducted to determine whether this association is serotype-specific.Keywords
This publication has 17 references indexed in Scilit:
- Viral Load of Human Papilloma Virus 16 as a Determinant for Development of Cervical Carcinoma In SituJournal of Lower Genital Tract Disease, 2001
- Type-Specific Persistence of Human Papillomavirus DNA before the Development of Invasive Cervical CancerNew England Journal of Medicine, 1999
- Prospective seroepidemiologic study of human papillomavirus infection as a risk factor for invasive cervical cancerJNCI Journal of the National Cancer Institute, 1997
- Epidemiology of Genital Human Papillomavirus InfectionThe American Journal of Medicine, 1997
- Seropositivities to Human Papillomavirus Types 16, 18, or 33 Capsids and to Chlamydia trachomatis Are Markers of Sexual BehaviorThe Journal of Infectious Diseases, 1996
- Comparison of Development of Serum Antibodies to HPV16 and HPV33 and Acquisition of Cervical HPV DNA Among Sexually Experienced and Virginal Young GirlsSexually Transmitted Diseases, 1996
- Data Quality and Quality Control of a Population-Based Cancer Registry: Experience in FinlandActa Oncologica, 1994
- Association of Genital Infection with Specific Chlamydia trachomatis Serovars and RaceThe Journal of Infectious Diseases, 1992
- CHLAMYDIA TRACHOMATIS IMMUNOTYPES IN FINLANDActa Pathologica Microbiologica Scandinavica Series B: Microbiology, 1987
- Immunologic Relationship Between Genital Tric, Lymphogranuloma Venereum, and Related Organisms in a New Microtiter Indirect Immunofluorescence TestAmerican Journal of Ophthalmology, 1970