Central venous oxygen saturation during hypovolaemic shock in humans
- 1 February 1993
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 53 (1) , 67-72
- https://doi.org/10.3109/00365519309092533
Abstract
Madsen P, Iversen H, Seeker NH. Central venous oxygen saturation during hypovolaemic shock in humans. Scand J Clin Lab Invest 1993; 53: 67-72. We compared central venous oxygen saturation and central venous pressure (CVP) as indices of the effective blood volume during 50° head-up tilt (anti-Trendelenburg's position) induced hypovolaemic shock in eight healthy subjects. Head-up tilt increased thoracic electrical impedance from 31 (28-36) (median and range) to 34 (30-40) Ohm, mean arterial pressure (MAP) from 79 (70-88) to 86 (80-99) mmHg, heart rate (HR) from 67 (56-71) to 99 (78-119) beats min−1 (p−l (p−1 (p−1 and TPR to 22 (13-33) mmHg min−1 (p<0.02). During tilting CVP decreased from 3 (1-6) to 1 (-3-5) mmHg (p<0.05) but thereafter remained stable. In contrast, central venous oxygen saturation showed a linear decrease with time from 0.75 (0.69-0.78) at rest to 0.60 (0.49-0.67) (p<0.01) when presyncopal symptoms appeared. Central venous catheterization is a tool for measurement of central venous oxygen saturation in addition to recording of CVP. The results suggest that a reduced central blood volume is reflected more clearly in central venous oxygen saturation than in CVP.Keywords
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