Staphylococcus aureus Mutants Selected by BMS-284756
Open Access
- 1 November 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (11) , 3273-3275
- https://doi.org/10.1128/aac.45.11.3273-3275.2001
Abstract
BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA , and grlB , were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in S. aureus .Keywords
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