Asymmetric Catalytic C−H Activation Applied to the Synthesis of Syn-Aldol Products
- 1 December 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (26) , 4153-4156
- https://doi.org/10.1021/ol006671j
Abstract
Rh2(R-DOSP)4-catalyzed decomposition of methyl phenyldiazoacetate in the presence of tetraalkoxysilanes results in the asymmetric synthesis of syn-aldol products. This catalytic asymmetric intermolecular C−H activation proceeds by means of a rhodium−carbene-induced C−H insertion.Keywords
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