Plant Based Antiamoebic Drugs; Part II1. Amoebicidal Activity of Parthenin Isolated fromParthenium hysterophorus2
- 1 April 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 54 (02) , 120-122
- https://doi.org/10.1055/s-2006-962366
Abstract
Parthenin, an α-methylene-γ-lactone sesquiterpene isolated from Parthenium hysterophorus is shown to possess antiamoebic activity. This activity was tested in vitro against axenic and polyxenic cultures of Entamoeba histolytica and was found to be comparable to that of the standard drug metronidazole. The acute toxicity of parthenin has been determined and this natural product was found effective in experimental hepatic amoebiasis.Keywords
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