IQGAP proteins are integral components of cytoskeletal regulation
Open Access
- 1 June 2003
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 4 (6) , 571-574
- https://doi.org/10.1038/sj.embor.embor867
Abstract
IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca2+/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E‐cadherin‐mediated cell–cell adhesion and β‐catenin‐mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.Keywords
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