Chemoenzymatic Synthesis of (S)-(-)-Frontalin Using Bacterial Epoxide Hydrolases
- 1 February 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (02) , 156-158
- https://doi.org/10.1055/s-1997-1153
Abstract
The pheromone (S)-(-)-frontalin (1) was synthesized in five steps in 94% ee via a chemoenzymatic route. In the key step, 2-methyl-2-(pent-4-enyl)oxirane [(±)-7a] was resolved employing lyophilized cells of Rhodococcus equi IFO 3730 (E=39).Keywords
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