Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
Open Access
- 1 April 1995
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 95 (4) , 1545-1552
- https://doi.org/10.1172/jci117827
Abstract
We previously described a new mouse model for multigenic obesity, designated BSB. We now report the use of a complete linkage map approach to identify loci contributing to body fat and other traits associated with obesity in this model. Four loci exhibiting linkage with body fat, or with the weights of four different fat depots, residing on mouse chromosomes 6, 7, 12, and 15, were identified and confirmed by analysis of additional BSB mice. Each of the four loci differed with respect to their effects on the percent of body fat, specific fat depots and plasma lipoproteins. The loci exhibited allele-specific, non-additive interactions. A locus for hepatic lipase activity was co-incident with the body fat and total cholesterol loci on chromosome 7, providing a possible mechanism linking plasma lipoproteins and obesity. The chromosome 7 locus affecting body fat, total cholesterol and hepatic lipase activity was isolated in congenic strains whose donor strain regions overlap with the chromosome 7 BSB locus. These results provide candidate genes and candidate loci for the analysis of human obesity.Keywords
This publication has 49 references indexed in Scilit:
- A Genetic Linkage Map of the Mouse: Current Applications and Future ProspectsScience, 1993
- Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).1993
- Stress and lipoprotein metabolism: Modulators and mechanismsMetabolism, 1993
- Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipaseJournal of Lipid Research, 1993
- Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.Journal of Clinical Investigation, 1993
- Polygenic control of autoimmune diabetes in nonobese diabetic miceNature Genetics, 1993
- Anchored reference loci for comparative genome mapping in mammalsNature Genetics, 1993
- Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1993
- Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome regionNature Genetics, 1992
- Hepatic lipase purification and characterizationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984