Antiallergic Activity of Andrographolides Isolated from Andrographis Paniculata (Burm. F) Wall

Publisher Website
Google Scholar
Abstract
Andrographis paniculata is widely used in traditional remedies in India in a number of clinical conditions including allergic manifestations. Two diterpenes, andrographolide and neoandrographolide, isolated from the plant, were evaluated for their antiallergic activity. These were tested for anti-PCA (Passive cutaneous anaphylaxis) and mast cell stabilizing activities in rats. Significant anti-PCA activity was observed. The compounds also possessed mast cell stabilizing activity against compound 48/80 and in sensitized mast cells, against egg albumin induced degranulation. The activities were found to be comparable to disodium cromoglycate.