Susceptibifity of Bacteroides fragilis to spectinomycin

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Abstract
Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of spectinomycin were determined for 100 recent clinical isolates of Bacteroides fragilis. Most strains were inhibited by 16 μg/ml, and killed by concentrations only slightly higher. Results were not affected significantly by the use of different media, by the addition of serum, or by the use of large inocula, but there was a striking diminution of activity in acid solutions. Limited study suggests that B. fragilis becomes resistant to the drug slowly in vitro. Reported peak serum concentrations of spectinomycin following intramuscular injection in man are considerably in excess of MTCs and MBCs of B. fragills.

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