Palladation of 8-methylquinoline and related 2-substituted derivatives: evidence for in-plane metallation of methyl groups
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 8,p. 344-345
- https://doi.org/10.1039/c39780000344
Abstract
8-Methylquinoline reacts with palladium acetate to give palladation at the 8-methyl group and similar metallations occur for 2-substituted derivatives where one would expect the substituent R to allow chelate ring formation (R = CH:NMe, CO2H, or CH2OH) but not where R = Me, Br, or CHO; evidence is presented for metallation occurring when the ligand plane and the co-ordination plane are coincident.Keywords
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