RETINOIDS AS REGULATORS OF MACROPHAGE FUNCTION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (3) , 467-472
Abstract
Retinol (vitamin A) and retinoic acid, at concentrations in the physiological range, exerted potent regulatory effects on the function of [human] macrophages; suppressing the expression of Fc receptors and the subsequent phagocytosis of opsonized cells, but enhancing production of the tumoricidal enzyme arginase. Another dietary essential lipid-soluble molecule, arachidonic acid, from which a number of active molecules known to regulate cellular function are derived, had no effect on macroiphage receptor expression or phagocytosis.