Hepatic Injury in Chronic Hypervitaminosis A

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Abstract
A 6-year-old girl who suffered from chronic hypervitaminosis A developed hepato-splenomegaly, hepatic dysfunction, and hypersplenism. A liver biopsy specimen displayed large lipid laden Kupffer's cells which were shown to contain vitamin A by fluorescence microscopy. Electron microscopically hepatic injury was indicated by increased lysosomes, focal cytoplasmic degradation, and numerous "light" and "dark" cells. These nonspecific indications of liver cell damage may reflect intracellular release of the biologically active alcohol of vitamin A.

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