Intestinal pH and propulsion: an explanation of diarrhoea in lactase deficiency and laxation by lactulose
- 1 March 1976
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 28 (3) , 192-195
- https://doi.org/10.1111/j.2042-7158.1976.tb04129.x
Abstract
Acidification of the lumen of guinea-pig isolated intestine increases peristaltic activity. A low colonic pH might therefore contribute directly to the diarrhoea induced by lactose in lactase-deficient subjects, and to the laxative effect of lactulose.Keywords
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