EFFECTS OF A NEW BETA-ADRENOCEPTOR BLOCKING-AGENT, S-596 (AROTINOLOL), ON ISOLATED DOG CORONARY-ARTERIES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 263  (2) , 208-216
Abstract
Effects of S-596 on dog coronary arteries were investigated in vitro. S-596 produced concentration-dependent relaxations of coronary arterial strips under K+-, prostaglandin (PG) F2.alpha.- or PGE2-contracture. S-596-induced relaxations of the strips were not influenced by tetraethylammonium or tranylcypromine, but restored by additional Ca2+ or prevented by prior Ca2+ administration. In distal portions of coronary arteries, S-596 significantly inhibited concentration-dependent relaxations of the strips induced by norepinephrine and reversed to weak contractions. In proximal portions, S-596 significantly inhibited concentration-dependent contractions induced by norepinephrine. Evidently S-596 has a nonspecific relaxant effect on isolated dog coronary arteries maybe through impairment of Ca2+ availability and simultaneously has an .alpha.-adrenoceptor blocking effect, particularly on large coronary arteries.