Transcriptional derepression of the murine Cyp1a‐1 gene by mevinolin

Abstract
In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P1450) and Nmo-1[N...

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