Effects of vasopressin and cyclic AMP on water transport at arachnoid villi of cats.

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Abstract
The effects of vasopressin and cyclic[c]AMP on water transport at arachnoid villi into the superior sagittal sinus were examined using the isolated meninges preparations of cats. The meninges preparation, the superior sagittal sinus of which was opened at the midline of the outer surface, was held between 2 polyethylene tubes. The tubes were fixed vertically in the way that the opened surface of the sinus was directed downward and arachnoid surface upward. Water transport was determined by measuring the tritiated water dripping through the membrane preparation. Vasopressin from less than 50-500 .mu.units/ml accelerated the water transport and this effect was dose-dependent. cAMP from 0.5-10 mM was proved to manifest the same effect as vasopressin. This effect of cAMP appeared rapidly in comparison with that of vasopressin, suggesting that the effect of vasopressin may be manifested through cAMP. From these findings a physiological role of vasopressin in CSF was discussed regarding the regulation of intracranial pressure.

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