Impact of Smoking Status on the Biological Behavior of Lung Cancer
- 27 August 2007
- journal article
- review article
- Published by Springer Nature in Surgery Today
- Vol. 37 (9) , 725-734
- https://doi.org/10.1007/s00595-007-3516-6
Abstract
Cigarette smoking is the most established risk factor for lung carcinogenesis; however, its effects on the progression of lung cancer are still unclear. We reviewed the clinical investigations on this issue, which imply that smoking status is a treatment predictor and prognostic factor for several subtypes of lung cancer. Moreover, gene alterations and various protein expressions of tumor progression were recognized more frequently in the tumor tissues of smokers than in those of the never smokers. A cellular analysis revealed that tobacco-specific chemical compounds cause genetic or epigenetic alterations, modulate expressions of large numbers of genes that include molecules related to proliferation, invasion and metastasis, and deteriorate anti-tumor immunity. Our findings suggest that smoking promotes the progression of lung cancer, and that elucidating the molecular mechanisms may help to clarify the therapeutic targets.Keywords
This publication has 94 references indexed in Scilit:
- Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival resultsBritish Journal of Cancer, 2006
- Smoking Status as a Prognostic Factor in Patients with Stage I Pulmonary AdenocarcinomaThe Annals of Thoracic Surgery, 2006
- Non–Small-Cell Lung Cancer Vaccine Therapy: A Concise ReviewJournal of Clinical Oncology, 2005
- The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through β-adrenergic transactivation of EGF receptorsZeitschrift für Krebsforschung und Klinische Onkologie, 2005
- Loss of heterozygosity and DNA damage repair in Saccharomyces cerevisiaeMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
- Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-κB by Suppressing Activation of I-κB α Kinase in Human Non-Small Cell Lung CarcinomaCancer Research, 2004
- Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancersOncogene, 2002
- Aromatic DNA adducts in lymphocytes of humans working at high and low traffic density areasChemico-Biological Interactions, 1996
- Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular DiseaseNew England Journal of Medicine, 1996
- Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130FEBS Letters, 1991