Glucose Metabolism of Haemonchus contortus Adults: Effects of Thiabendazole on Susceptible versus Resistant Strain

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Abstract
Analyses of the in vitro glucose metabolism of H. contortus adults [from lambs] confirmed a complex series of end-products, ethanol, n-propanol, propionate, acetate and CO2, as the major end-products of catabolism. No difference in end-product accumulation was seen between the cambendazole sensitive (BPL) and cambendazole resistant (CR) strains. Thiabendazole (5 mM) in vitro depressed ethanol, propanol, acetate and propionate accumulation by .apprx. 42% in the BPL strain. In the resistant strain (CR), these end-product accumulations increased by 50% when the worms were exposed to drug in vitro and 80% when exposed in vivo. Resistance manifested by the CR strain appeared to be associated with the ability to increase its C flow in the presence of thiabendazole.

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