Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning
- 1 March 2005
- journal article
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 35 (S1) , S45-S47
- https://doi.org/10.1038/sj.bmt.1704846
Abstract
The optimal preparation for stem cell transplantation (SCT) in children with congenital immunodeficiencies is currently unknown. In all, 81 children with immunodeficiency underwent 82 SCTs using reduced-intensity conditioning (RIC). The incidence of significant GVHD was low; viral reactivation was prominent with an unexpected increase in EBV reactivation; immune reconstitution was similar between different donor groups and comparable to conventional SCT. Overall, 68/81 (84%) survive with no significant difference between donor types or between severe combined immunodeficiency (SCID) and non-SCID diseases. Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT.Keywords
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