Synthesis and analgesic effect of N-substituted 5-arylidene-6-methyl-3-(4H)-pyridazinones.

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Abstract
Two methods of N-substitution was applied to 5-arylidene-6-methyl-3-(4H)-pyridazinones. The resulting derivatives were tested in order to determine the area of pharmacological activity. Most compounds exhibited a dose-dependent analgesic activity in mice. Introduction of a benzoyl substituent in the 2-position of the pyridazinone ring 2j induced the most potent activity.