Physiological effects of carbon dioxide gas introduced into coronary arteries

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Abstract
Carbon dioxide gas is well tolerated when introduced directly into coronary arteries of anesthetized dogs. There were no fatalities in either normal or freshly infarcted hearts. Intracoronary carbon dioxide gas produced no persisting changes in the electrocardiogram or in blood pressure when injected slowly. Rapid injections under pressure produced extrasystoles at the time of injection and caused some subsequent changes of short duration in the electrocardiogram. These short duration changes were alterations of S-T segment deviations (which purposely had been produced previously in the control period) toward a more normal configuration. During this same period of time coupled extrasystoles produced in the control period were suppressed.