Positive interaction of the β2‐agonist CHF 4226.01 with budesonide in the control of bronchoconstriction induced by acetaldehyde in the guinea‐pigs
Open Access
- 1 February 2005
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 144 (3) , 422-429
- https://doi.org/10.1038/sj.bjp.0706096
Abstract
Pretreatment of anaesthetized guinea‐pigs with either CHF 4226.01 (8‐hydroxy‐5‐[(1R)‐1‐hydroxy‐2‐[N‐[(1R)‐2‐(p‐methoxyphenyl)‐1‐methylethyl]amino]ethyl] carbostyril hydrochloride), formoterol or budesonide reduced acetaldehyde (AcCHO)‐evoked responses in the lungs with a rank order of potency CHF 4226.01 (ED50 values, from 1.88 to 3.31 pmol) > formoterol (ED50 values, from 3.03 to 5.51 pmol) ≫ budesonide (ED50 values, from 335 to 458 nmol). The duration of action of CHF 4226.01 in antagonizing the airway obstruction elicited by AcCHO was also substantially longer than formoterol (area under the curve) at 10 pmol, 763±58 and 480±34, respectively; P2O as a peak, P50 values, 2.85 and 6.11 pmol, respectively; P50 value of budesonide (396 nmol) in preventing AcCHO‐evoked ITP increase was reduced when this glucocorticoid was combined with 0.1 pmol CHF 4226.01 (ED50 76 nmol; PPBritish Journal of Pharmacology (2005) 144, 422–429. doi:10.1038/sj.bjp.0706096Keywords
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