Hydroxyacetals, phthalans, and isobenzofurans therefrom
- 1 September 1983
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 61 (9) , 1987-1995
- https://doi.org/10.1139/v83-343
Abstract
A general method for the generation of isobenzofuran intermediates is described. Lithiated aromatic acetals are converted to hydroxyacetals (A) which may be cyclized to isobenzofurans by mild acid treatment through the 1-hydroxyphthalans (B). The isobenzofurans generated insitu are trapped by a variety of dienophiles to provide the expected oxo-bicyclo adducts (C). The mass and 1Hmr spectra of B and C are discussed.Keywords
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