Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression
- 1 January 1994
- journal article
- research article
- Published by Wolters Kluwer Health in Psychiatric Genetics
- Vol. 4 (3) , 185-191
- https://doi.org/10.1097/00041444-199400430-00009
Abstract
The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1, β3 and γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.Keywords
This publication has 1 reference indexed in Scilit:
- Dinucleotide repeat polymorphism at the human β1 subunit of the GABAAreceptor gene (GABRB1)Nucleic Acids Research, 1991