Effect of 3':5'-cyclic AMP on glucose transport in rat adipocytes.
- 1 December 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (12) , 4359-4363
- https://doi.org/10.1073/pnas.73.12.4359
Abstract
An indirect method for obtaining a reliable measure of the rate of glucose transport into adipocytes is described. Evidence is presented that altered levels of 3'':5''-cyclic[c]AMP can incluence the transport of glucose into adipocytes. When cAMP levels were lowered with antilipolytic agents (insulin, nicotinic acid, or clofibrate), rates of glucose transport were increased. In contrast, when adipose tissue levels of cAMP were elevated by lipolytic hormones or theophylline, glucose transport was inhibited. Insulin no longer increased glucose transport when cAMP levels were elevated by lipolytic agents. Agents that can raise cAMP but inhibit lipolysis (procaine, amitryptyline, and phenylethylbiguanide) reduced the rate of glucose transport. Other data are presented that are consistent with the conclusion that cAMP inhibits glucose transport into adipocytes.This publication has 34 references indexed in Scilit:
- Effect of glucocorticoids on the glucose transport system of isolated fat cells.Journal of Biological Chemistry, 1975
- Deuterium oxide stimulates glucose metabolism and inhibits lipolysis in rat epididymal adipose tissueBiochemical and Biophysical Research Communications, 1975
- Time course of insulin-receptor binding and insulin-induced lipogenesis in isolated rat fat cells.Journal of Biological Chemistry, 1975
- Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action.Journal of Clinical Investigation, 1975
- Evidence for the involvement of cyclic-3′,5′-adenosine monophosphate in glucose utilization by isolated rat epididymal adipose cellsBiochemical and Biophysical Research Communications, 1967
- GLUCOSE UPTAKE BY INCUBATED RAT EPIDIDYMAL ADIPOSE TISSUE - RATE-LIMITING STEPS AND SITE OF INSULIN ACTION1965
- METABOLISM OF ISOLATED FAT CELLS .I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM + LIPOLYSIS1964
- Studies on the Metabolism of Adipose Tissue. XIII. The Effect of Anaerobic Conditions and Dietary Regime on the Response to Insulin and Epinephrine*Biochemistry, 1963
- Studies on the Metabolism of Adipose Tissue. XI. Activation of Phosphorylase by Agents Which Stimulate Lipolysis*Biochemistry, 1962
- ADENOSINE 3',5'-PHOSPHATE IN BIOLOGICAL MATERIALS .1. PURIFICATION AND PROPERTIES OF CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE AND USE SF THIS ENZYME TO CHARACTERIZE ADENOSINE 3',5'-PHOSPHATE IN HUMAN URINE1962