Increased Chloride Reabsorption as an Inherited Renal Tubular Defect in Familial Type II Pseudohypoaldosteronism

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Abstract
HYPERKALEMIA is a common electrolyte disorder. Among its common causes are renal insufficiency; adrenal insufficiency; hyporeninemic hypoaldosteronism, usually associated with diabetes mellitus, mild renal insufficiency, tubulointerstitial nephritis, or a combination of these conditions; isolated hypoaldosteronism; and pseudohypoaldosteronism, a disorder characterized by salt wasting, hypotension, and aldosterone resistance. There also exists a rare hyperkalemic syndrome associated with a normal glomerular filtration rate and hypertension.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Although several hypotheses have been proposed to explain the impaired renal potassium secretion in this hyperkalemic syndrome, its exact pathogenesis, especially at the molecular level, is not known.