Effect of Raw Materlals and Processing on the Quality of Granules Prepared from Microcrystalline Cellulose-Lactose Mixtures

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Abstract
Wet granulation, using lactose as an excipient, is widely used in the pharmceutical industry. The use of micro-crystalline cellulose, as part of the excipient, may offer several advantages. The purpose of this work is to investigate the effect of ingredients and processing variables on granule quality. For these studies, only two-component system granulated with water in a planetary mixer were considered. The variables studied included the volume of granulating solution, type of lactose, dissolved material (other than binder) in the granulating solution, massing time, mesh size for wet screening and drying technique (oven and fluidized bed drying).