THE EFFECT OF TESTOSTERONE AND ALLIED COMPOUNDS ON THE MINERAL, NITROGEN, AND CARBOHYDRATE METABOLISM OF A GIRL WITH ADDISON'S DISEASE 12

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Abstract
The adm. of either methyl testosterone or testosterone propionate, in addition to maintenance doses of desoxycorticosterone acetate and sodium chloride-, resulted in: a gain in body wt.; a diminution in the urinary excretion of N, K and Na; and (3) a marked fall in the serum K conc. No significant changes in fasting blood sugar concs. were noted. The adm. of anhydro-hydroxy-progesterone or of methyl androstenediol, under similar circumstances, prompted a decrease in urinary N excretion but did not induce a prompt gain in body wt. Methyl testosterone therapy did not prevent the development of symptoms and signs of acute adrenal cortical insufficiency when DCA was withdrawn. Testosterone propionate relieved the patient of all signs and symptoms of acute adrenal insufficiency after the discontinuation of DCA therapy. The marked lowering in the serum K conc. while the patient was receiving testosterone was not associated with clinical evidences of muscular weakness or paralysis. On the contrary, the patient seemed to benefit from the testosterone, as evidenced by gain in wt., growth in stature, and apparent increase in strength and endurance.