Non-Metastatic Hepatic Dysfunction Associated with Renal Carcinoma

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Abstract
A retrospective computer anaalysis of 102 patients treated for renal tubular carcinoma revealed 7 patients who presented with nonmetastatic hepatic dysfunction. Of these 7 patients 5 also had the triad of fever, weight loss and fatigue. Only 1 patient survived more than 10 yr after nephrectomy. A review of the literature on nonmetastatic hepatic dysfunction revealed a significant interval between onset of symptoms and detection of the underlying renal malignancy, as well as a poor overall survival rate if the syndrome persisted after nephrectomy.