Development of ‘Primary’ Hyperparathyroidism during Lithium Therapy: Longitudinal Study

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Abstract
The bone mineral content and the serum levels of immunoreactive parathyroid hormone (iPTH), and protein-corrected Ca and Mg were measured in 13 manic depressive patients before and during treatment with Li. Initially, all 4 parameters were normal. During the treatment, the bone mineral decreased and the serum levels of iPTH, Ca and Mg increased. Although altered metabolism of parathyroid hormone cannot be ruled out, these data, together with other observations, suggest that a mild primary hyperparathyroidism sets in quite early after institution of Li therapy.

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