Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine
- 20 February 1991
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 47 (4) , 496-498
- https://doi.org/10.1002/ijc.2910470404
Abstract
Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.Keywords
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