Controlling Abl: auto-inhibition and co-inhibition?
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 6 (1) , 3-7
- https://doi.org/10.1038/ncb0104-3
Abstract
Auto-inhibition describes the capacity of proteins to adopt a self-imposed latent conformation. Recently, a crystal structure of the Abl tyrosine kinase has revealed its ability to auto-inhibit. However, a separate body of work suggests that other cellular proteins also inhibit Abl. To reconcile the crystal structure with Abl inhibitors, I propose that Abl is controlled by cellular 'co-inhibitors' that bind Abl, stabilizing the auto-inhibited conformation. The implication of co-inhibition on Abl function is discussed.Keywords
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