Excretion of Corticosteroid-Binding Globulin, Thyroxine-Binding Globulin and Total Protein in Adult Males with Nephrosis: Effects of Sex Hormones1

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Abstract
The plasma concentrations and urinary excretion of corticosteroid-binding globulin (CBG), thyroxine-binding globulin (TBG) and total protein were studied in 6 adult males with the nephrotic syndrome. Significant losses of both CBG and TBG occurred in these patients, representing plasma clearances of up to 1200 ml/day. Despite low to low-normal plasma thyroxine concentrations, the mean TBG concentration in this group was the same as the normal mean. This was in distinction to plasma CBG and 17-hydroxycorticosteroid concentrations, means for both of which were well below the normal means. Diethylstilbestrol produced increased urinary losses of CBG in 5 of 5 subjects treated and of TBG in 4 of 5 subjects. Also increased was total protein excretion in all 5 subjects. Methandrostenolone [δ1-dehydro-17αmethyltestosterone (Dianabol)] decreased TBG excretion (and slightly decreased total protein excretion) in 3 of 3 subjects studied but did not change excretion of CBG.

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