Thrombophilia Polymorphisms and Intrauterine Growth Restriction

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Abstract
Infante-Rivard et al. (July 4 issue)1 found no association between thrombophilic mutations and intrauterine growth restriction defined by a birth weight below the 10th percentile, as we2 and others3,4 have demonstrated, and they found an unexpectedly low rate of placental infarcts. Although the authors note that we used the 5th percentile for defining fetal growth restriction,2 they did not address other important differences between our study and their own.

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