Stimulatory Effect of Cyanidin 3-Glycosides on the Regeneration of Rhodopsin
- 10 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (12) , 3560-3563
- https://doi.org/10.1021/jf034132y
Abstract
Anthocyanins have been suggested to improve visual functions. This study examined the effect of four anthocyanins in black currant fruits on the regeneration of rhodopsin using frog rod outer segment (ROS) membranes. Cyanidin 3-glycosides, glucoside and rutinoside, stimulated the regeneration, but the corresponding delphinidins showed no significant effect. The formation of a regeneration intermediate was suggested to be accelerated by cyanidin 3-rutinoside. Their effects on the cGMP-phosphodiesterase activity in the ROS membranes were also investigated but found to be negligible. It was concluded that the major effect of anthocyanins in rod photoreceptors is on the regeneration of rhodopsin. Keywords: Rhodopsin; regeneration; 11-cis-retinal; anthocyanin; black currantKeywords
This publication has 12 references indexed in Scilit:
- Low amplification and fast visual pigment phosphorylation as mechanisms characterizing cone photoresponsesProceedings of the National Academy of Sciences, 2001
- Activation, Deactivation, and Adaptation in Vertebrate Photoreceptor CellsAnnual Review of Neuroscience, 2001
- Presence of Two Rhodopsin Intermediates Responsible for Transducin ActivationBiochemistry, 1997
- Is Chicken Green-Sensitive Cone Visual Pigment a Rhodopsin-like Pigment? A Comparative Study of the Molecular Properties between Chicken Green and RhodopsinBiochemistry, 1994
- Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulinNature, 1993
- Calcium-dependent regulation of cyclic GMP phosphodiesterase by a protein from frog retinal rodsNature, 1991
- Vaccinium myrtillus anthocyanosides are inhibitors of cAMP and cGMP phosphodiesterasesPharmacological Research Communications, 1988
- Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibriumFEBS Letters, 1982
- The preparation of 11-cis-retinalVision Research, 1978
- Pre-Lumirhodopsin and the Bleaching of Visual PigmentsNature, 1963