Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren

1 December 2002

journal article
Published by Springer Nature in Human Genetics

Vol. 111 (6) , 570-572
https://doi.org/10.1007/s00439-002-0825-0

Abstract

The purpose of this study was to assess the influence of single nucleotide polymorphism 3 (SNP3) of the apolipoprotein A-V (APOA5) gene on the serum triglyceride (TG) level in Japanese schoolchildren. To determine the frequency of the genotype, we analyzed 552 schoolchildren. The frequencies of the T/T, T/C and C/C genotypes of the APOA5 gene were 225 (40.8%), 263 (47.6%) and 64 (11.6%), respectively. The serum TG level was significantly different among the genotypic groups after adjustments for age, gender and obesity index (T/T 71.6±34.8 mg/dl, T/C 80.7±36.1 mg/dl, C/C 94.4±69.4 mg/dl, PAPOA5 gene appears to be a genetic risk factor for hypertriglyceridemia in Japanese children.

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