Genetic control of adrenergic receptors on human platelets. A twin study
- 1 August 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 64 (2) , 105-109
- https://doi.org/10.1007/bf00327103
Abstract
It was examined whether genetic factors are involved in the expression of alpha-2 adrenergic receptors on human platelets, as measured with 3H-yohimbine as ligand. The twin series comprised 17 monozygotic and 15 dizygotic adult, healthy, male, drug-free twin pairs. For control of intraindividual and interassay variation, 13 unrelated pairs of subjects were examined. Bmax values for 3H-yohimbine binding (range 91–305 fmol/mg protein) proved to be under considerable genetic control; this was not the case for KD values. Different possible genetic mechanisms are discussed.This publication has 17 references indexed in Scilit:
- 3H-Imipramine binding in platelets: Influence of varying proportions of intact platelets in membrane preparations on bindingPsychopharmacology, 1983
- Signal transformation mediated by membrane receptors for hormones and neurotransmittersMolecular Immunology, 1982
- Age-dependent decrease of α2-adrenergic receptor number in human plateletsEuropean Journal of Pharmacology, 1982
- Adrenergic Receptors in ManNew England Journal of Medicine, 1982
- Agonist Regulation of α-Adrenergic Receptor Responses in ManJournal of Cardiovascular Pharmacology, 1982
- Genetics of the low density lipoprotein receptor:Clinical Genetics, 1981
- Genetics of the low density lipoprotein receptor:Clinical Genetics, 1981
- Characterization of α2-adrenergic receptors on human platelets using [3H]yohimbineBiochemical and Biophysical Research Communications, 1980
- The Syndromes of Androgen ResistanceNew England Journal of Medicine, 1980
- Synthetic α-adrenergic agonists are potent α-adrenergic blockers in human plateletsNature, 1978