Hemodynamic effects of isometric exercise and mental arithmetic in hypertension treated with selective and nonselective β-blockade

Publisher Website
Google Scholar
Abstract
Hypertensive patients have an unfavorable pressor response to exogenous epinephrine during nonselective .beta.-blockade. Hemodynamics were studied during epinephrine release induced by handgrip exercise and mental arithmetic to examine the clinical relevance of this phenomenon. Hypertensive patients (22) were examined in a double-blind crossover experiment with placebo, propranolol (240 mg/day), placebo-washout and metoprolol (300 mg/day). Changes induced by stress tests for systolic and diastolic blood pressure, heart rate (HR) and forearm blood flow (FBF) were of the same order on both .beta.-blockers. Rises in HR and FBF were equally reduced by both drugs. Neither handgrip exercise nor mental arithmetic induced significant differences in reaction during selective and nonselective .beta.-blockade.

This publication has 10 references indexed in Scilit: