Diet as Source of Serum Cholesterol in Man.

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Abstract
Continued ingestion (for 8 weeks) of a constant daily dsoe of radioactive cholesterol is believed to suppress cholesterol synthesis by liver tissue and to replace it as a source of serum cholesterol. The maximum specific radioactivity of serum cholesterol (this reaches a plateau after 4 to 5 weeks) divided by the specific radioactivity of dietary cholesterol, X100, gives the percentage of serum cholesterol that comes from the diet. This percentage is further believed to represent the percentage of serum cholesterol that would come from the liver if the diet supplied none. The remaining percentage is presumed to come from synthesis by extrahepatic tissues. In 11 adult human subjects ingesting 1.4 or 4.4 g cholesterol/day, the diet supplied 1/4 to 1/3 of the total serum cholesterol.

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