Double Diastereoselection Operative During π-Facially Selective Addition of Chiral 1-Cyclopentenyllithium Reagents to (7R)-7-Methyl-7-Vinylbicyclo[3.2.0]Hept-2-En-6-One
- 1 March 1987
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 17 (4) , 369-375
- https://doi.org/10.1080/00397918708063913
Abstract
Reaction of the title cyclobutanone with chiral cyclopentenyllithium reagents occurs exclusively from the convex face with low diastereoselectivity. Nonetheless, polycyclic networks with as many as nine stereogenic centers can be elaborated in very few steps.Keywords
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