LYMPHADENOPATHY INDUCED BY ETHOTOIN (PEGANONE)

Publisher Website
Google Scholar
Abstract
Ethotoin (Peganone), an anticonvulsant drug with the formula 3-ethyl-5-phenylhydantoin, first introduced in 1956,1may produce clinical and pathological alterations similar to malignant lymphomas. If this condition is not recognized as a drug reaction rather than a neoplasm, such therapy as nitrogen mustard or irradiation may be instituted and the patient or his family may be told that he has an incurable disease. The following case forcibly brought this to our attention. Report of a Case A 7-year-old mentally retarded boy was admitted to St. Louis Children's Hospital Nov. 21, 1957, with a seven-week history of cervical lymphadenopathy. A diagnosis of "convulsive disorder" was made when the child was 3 years of age. The patient had a history of a marked allergic rhinitis. Recent therapy included metharbital (Gemonil) and mephobarbital (Mebaral). In September, 1957, 0.25 Gm. of ethotoin given twice daily was added to the regimen and increased to 0.5

This publication has 0 references indexed in Scilit: